allelic losses การใช้

• Thus, tumor progression in basal cell carcinoma, allelic loss or hypermethylation of the T-cadherin gene promoter region.
• The loss of NKX3-1 expression is frequently observed in prostate tumorigenesis and has been seen to be a result of allelic loss, methylation, and post transcriptional silencing.
• Interestingly, humans with double allelic loss of CCR5 are virtually immune to HIV acquired via the sexual route ( though can be infected by IV transmission of CXCR4 tropic viruses ).
• ZNF541 and PNMAL2, in relation to TMEM143, have been documented as having a role in the allelic loss of q13.3 of chromosome 19 . This loss results in documented cases of malignant gliomas, neuroblastomas, and ovarian carcinomas, all suggesting a tumor suppression gene or genes in this region.